Gary Medel scored his first goal for Inter Milan as they beat leaders Roma to go top of Serie A.
Midfielder Medel, who joined Inter from Cardiff at the start of last season, drove a long-range shot past on-loan Arsenal keeper Wojciech Szczesny.
Roma dominated the second half but could not find a way past Inter goalkeeper Samir Handanovic as they lost for the second time this season.
The visitors finished with 10 men after midfielder Miralem Pjanic was sent off.
Pjanic was booked just before half time and received a second yellow card for handball in the 72nd-minute as Roma's five-match winning run in the league came to an end.
Pjanic had earlier been close to an equaliser as Roma battled to recover from Medel's 31st-minute strike but his shot was saved by Handanovic, who then blocked the follow-up from former Chelsea winger Mohamed Salah.
Handanovic also twice kept out headers from former Manchester City forward Edin Dzeko, who was slow to react to a chance to give Roma a first-half lead after a Maicon shot had also been saved.
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