Frank Lampard's team are back in action 48 hours after the shocking 3-1 defeat away to Arsenal on Boxing Day.
The head coach will be demanding a big response from his team, which will contain wholesale changes, against Dean Smith's in-form Villa.
Hakim Ziyech is confirmed out, while Callum Hudson-Odoi, Jorginho, N'Golo Kante and Edouard Mendy are tipped to start for the hosts.
Beyond that it is not easy to guess the starting line-up but stay tuned below for confirmed team news once it is released an hour before the match.
"There will be some changes and I knew that anyway," Lampard said after the Arsenal loss. "I am certainly not going to bang the drum about the quick turnaround after our performance today. That's not the point.
"We are playing two games in two days and that would have happened anyway. Some of those will happen because of how the game went and people will have to come in and inject energy and personality."