RealMadrid will go top by two points if they beat Real Betis at 19:45 GMT, while Zinedine Zidane's side will still have a game in hand on the defending champions after that.
The Italian side finished second, eight points behind RealMadrid in Group C, on 10 points, while Braga held on to third place and Europa League football with four points.
Marcos Llorente and Angel Correa both scored twice to help a depleted Atletico Madrid thrash visitor Las Palmas 5-0 in LaLiga on Saturday, as manager Diego Simeone rested key players ahead of a midweek ChampionsLeague last-16 tie at Inter Milan
Dani Ceballos scored twice on his first league start for RealMadrid as they beat struggling Alaves. The 21-year-old Spanish midfielder, signed from Real Betis in the summer, held off two defenders before striking home his first.
That made it six hat-tricks for Kane in 2017 and five goals in the ChampionsLeague this season. Spurs are now top of Group H alongside RealMadrid, who beat Borussia Dortmund in Germany this evening.
Napoli's Giacomo Raspadori scored a second half goal to secure a 1-0 victory at Union Berlin in their ChampionsLeague Group C match on Tuesday and stretch their opponents' losing run to nine straight games in all competitions.
Manchester City bounced back from the disappointment of the ChampionsLeague quarter-final exit to RealMadrid as Bernardo Silva's late goal sunk Chelsea at Wembley to seal a place in the FA Cup final.
Leipzig - who face RealMadrid in the last 16 of the ChampionsLeague in February and have now lost their last three matches in Germany's top flight - sit fourth on the same points as Borussia Dortmund, who have played a game fewer.
RealMadrid loanee Alvaro Medran spoke before the game of the need to exploit Barcelona's weaknesses, but Juan Rodriguez's own goal gave Barca the lead and Getafe provided scant evidence that they believed in a comeback, even after Messi missed