Barcelona's La Liga title hopes were hit as they followed up their famous Champions League win over Paris St-Germain with a defeat at struggling Deportivo La Coruna.
Luis Enrique made five changes from the side who beat PSG 6-1, with the injured Neymar ruled out.
Barca were below par, falling behind to a close-range Joselu finish.
Luis Suarez equalised seconds after the restart but an Alex Bergantinos header sealed Depor's win.
Real Madrid will go top by two points if they beat Real Betis at 19:45 GMT, while Zinedine Zidane's side will still have a game in hand on the defending champions after that.
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