It was their third defeat of the season after eight fixtures. The result leaves Ole Gunnar Solskjaer's men in 12th place, two points above relegation places.
After a good first season on Merseyside, Deulofeu fell out of favour and manager Ronald Koeman allowed him to spend the second half of the last campaign in Italy.
Klopp's men suffered a disappointing defeat against Red Star in their last outing which leaves them in a precarious position with just two points separating the four teams.
Eddie Howe's side are only off the bottom of the Premier League on goal difference and have lost their opening four games in aseason for only the third time.
However, second-half goals from Kevin Gameiro and Ludovic Ajorque saw Strasbourg threaten to produce a shock comeback. Alexander Djiku was then sent off for the visitors after two bookable offences.
The win also moved Ernesto Valverde's men12 points clear of them on the table. Ivan Rakitic struck the only goal of the game midway through the first half, dinking the ball over Thibaut Courtois.
Mourinho made a double substitution at half-time, bringing on Marcus Rashford and Henrikh Mkhitaryan, and the former gave United hope with 12 minutes remaining, nodding in a terrific cross by the otherwise quiet Romelu Lukaku.
Three goals from David Silva, Sergio Aguero and IIkay Gundogan ensured victory for Guardiola's men. Forward, Anthony Martial's lone strike was not enough to get a point for Jose Mourinho's side.
A solitary strike in the second half by the hosts ended Enyimba's aspirations of a possible third Champions League triumph this season. Both teams were evenly matched in the first half though the hosts had the better chances.
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Newcastle made the perfect start when Anthony Gordon won a penalty with just three minutes played and Alexander Isak converted from 12 yards after a lengthy check by the video assistant referee (VAR).
A goal each from Vidal, Braithwaite, Alba and Messi handed Quique Setien's men the victory in the encounter. Messi's goal in the game made him the first player to score 20 or more La Liga goals in 12 consecutive seasons.
However, two late goals from Kevin De Bruyne and Jonjo Shelvey ensure both teams played a draw at St. James' Park. "For Man City it is a different story.
Messi has continued from where he stopped last season scoring 19 goals, providing 12 assists in 22 La Liga matches before fixtures were put to a stop due to the Coronavirus pandemic.