Raphael Varane scored the winner on the night at Old Trafford, heading home Aaron Wan-Bissaka's cross from close range as United struggled to find their rhythm against an electric Wolves side.
Iheanacho, 19, added the third from close range, then the teenager rounded the keeper to seal an emphatic win. Stoke conceded four goals for the third straight Premier League game.
The champions went ahead in the first half through Luis Suarez, who nodded in Ivan Rakitic's cross from close range. On his 100th competition appearance the closest Lionel Messi came to scoring was when he hit the crossbar.
A sensational long-range drive from Vinicius Jr gave Madrid an early lead at the Bernabeu. Bellingham then scored his 19th goal of the season from a sublime Vinicius pass before converting from close range after half-time.
Da L.E.S' unmistakable sound and performance style has solidified Da L E S's success as a member of the CÎROC Circle, an elite collection of South Africa's most prominent talents from across a broad range of specialities.
The Brazilian striker opened his account for us with two goals in the opening 45; the first a sumptuous piece of play that saw him chip the ball into the top corner from inside the area, before he nodded in from close range 13 minutes later
Jurgen Klopp's side fell behind when Willian capitalised on a Virgil van Dijk error early on but Curtis Jones pulled them level with a long-range effort which took a wicked deflection off Tosin Adarabioyo.
Pep Guardiola's side, taking part in the tournament after winning last season's Champions League, made the ideal start as Alvarez struck after 40 seconds, chesting in from close range after Nathan Ake's long-range strike hit the post.
In this truer test, the hosts' long unbeaten league run on Merseyside never looked under real threat until late on, when Alisson made two vital saves to deny Bruno Fernandes and Paul Pogba from close range.
Dani Carvajal fired in an excellent opener at the near post and Vinicius Jr chested in at close range from Rodrygo's cross before the break. Vinicius then finished low into the corner after 49 minutes for his second.
Marcus Thuram doubled Inter's lead before the break when he thundered home a spectacular long-range effort. Rafael Leao pulled one back for AC Milan but Mkhitaryan, Hakan Calhanoglu and Davide Frattesi put the game to rest.
Rooney, playing at No 10, then turned the match in the second half by equalising from close range and converting a penalty after substitute Marcus Rashford had been fouled.
It had taken Sevilla just five minutes to take the lead as Wissam Ben Yedder tapped in from close range after home defender Dejan Lovren fell over while trying to clear the ball.