But despite a nervy finale and with United enjoying almost 80% of possession, the Terriers clung on to record their first league win against United since 1952 and end a run of six league games without a win.
Burnley's hopes of forging a route back into the game took a turn for the worse when O'Shea lost possession near the halfway line before committing a professional foul on Dwight McNeil, earning a the defender a straight red card.
A Fernandinho slip inside his own box put Messi clear for his first, then Kevin de Bruyne lost possession allowing Andres Iniesta to set up the Argentine for a left-footed strike into the bottom corner.
Despite having 84% of possession in the first half and wasting numerous chances, Liverpool conceded a 58th-minute equaliser as Gustavo Hamer's header bounced off Conor Bradley and into his own net.
United had less than 40% possession, nine shots compared to Tottenham's 16 and only a third of the visitors six on target. The result was not enough to take Tottenham above rivals Arsenal and into the top four.
But in an instant Leicester were given a lifeline out of nowhere as Lucas Leiva -- deputising at centre-back for the injured Dejan Lovren -- gifted possession to Jamie Vardy inside the penalty area, who pounced on the opportunity to draw one
Betis offered little in response after the break as the home side monopolised possession, and two goals shortly before the hour mark, from Suarez -- who turned in a low Messi cross -- and Messi himself turned victory into a rout.
That was the system Mikel Arteta went for from the start, but it was the most central of those three centre backs - Pablo Mari - who was caught in possession early on to gift Chelsea the first chance of the game.
We were looking bright in possession, and looked like we had taken the lead when Rob Holding bundled the ball just over the line from a corner, but it was disallowed for offside.
And within 60 seconds Rashford announced his arrival, turning Bacary Sagna before crossing for Ibrahimovic to shoot over as United made a high-octane start to the second half, pressing and harrying City in an attempt to stop thepossession game