City, who had 10 shots in the first 15 minutes, added their second when Sergio Aguero sublimely lifted the ball over home goalkeeper Sergio Rico from close range.
It had taken Sevilla just five minutes to take the lead as Wissam Ben Yedder tapped in from close range after home defender Dejan Lovren fell over while trying to clear the ball.
Liverpool reached the FA Cup fifth round with an entertaining victory over Norwich in their first game since manager Jurgen Klopp announced he will leave at the end of the season.
Phil Foden sealed it, adding to the late goal he scored at the Etihad to give his side their first-leg lead with a fierce drive that found the Dortmund goal via the post.
Youri Tielemans produced one of the great FA Cup final goals to give Leicester City the trophy for the first time in their history with victory over Chelsea at Wembley.
The impressive James Trafford was kept busy in the Burnley goal and had already smothered Harvey Elliott's low drive before making a stunning fingertip stop to deny Mohamed Salah.
Phil Foden struck a stunning hat-trick as Manchester City continued to apply pressure to Premier League title rivals Arsenal and Liverpool with a commanding win over Aston Villa at Etihad Stadium.
Di Maria's right-wing delivery curled over Pogba and Kimpembe shook off the attentions of Nemanja Matic to send a controlled volley into the roof of De Gea's net.