The Blues were soon made to pay for their profligacy, after Karim Benzema equalised on the half-hour mark. Reece James, Hakim Ziyech and Kai Havertz were brought on in place of Azpilicueta, Pulisic and Werner with 20 minutes left.
Two goals from Tammy Abraham and Christian Pulisic gave the Blues all three points against Watford. However, Gerard Deulofeu did score a goal for the host at Vicarage Road.
The 21-year-old joined from Borussia Dortmund in a £58million deal over the summer, but has only played 90 minutes for the Blues on two occasions - against Sheffield United and Grimsby.
The Blues have loaned the United States international back to Dortmund for the remainder of the season before he will link up with his new team-mates in the summer.
Diego Costa and Marcos Alonso opened the scoring for the Blues at Stamford Bridge on Monday night but it was the third goal from Nemanja Matic which made Fabregas a history-maker.
The Blues who have already been confirmed league champions, have N'Golo Kante, Eden Hazard and Cesar Azpilicueta on the shortlist. Dele Alli, Christian Eriksen and Jan Vertonghem make the shortlist for Spurs.
Chelsea manager, Frank Lampard, on Friday suffered his first defeat as the Blues coach after his side conceded a late goal against Kawasaki Frontale in a pre-season friendly match in Yokohama.
Former Premier League champions, Chelsea have won the race ahead of Liverpool and Arsenal to sign 20-year-old Borussia Dortmund midfielder, Christian Pulisic.
Former loanees Tiemoue Bakayoko, Kenedy and Michy Batshuayi take the 14, 16 and 23 they have worn for the Blues previously. Mason Mount taking 19, Reece James 24 and Fikayo Tomori 29.
The Blues boss said this on Thursday during his pre-match press conference. Chelsea head to the match following a 4-1 victory against Sheffield United earlier this month before the international break.
Liverpool had to come from behind in the game, with Olivier Giroud opening the scoring for the Blues in the first half, and Christian Pulisic having a goal ruled out for offside.