The hosts' afternoon got worse when Iheanacho got a pass from Brown Ideye, rounded up three Chipolopolo defenders and slotted home the second three minutes from the half time break.
Then came Zaire-Emery's goal before the unfortunate Santos was shown a red card in the 18th minute. Mbappe made it 4-0 from the penalty spot before further strikes from Clauss, Kingsley Coman and Youssouf Fofana made it 7-0 at the break.
Ronaldo, rested for Wednesday's 7-1 Copa del Rey win at Cultural Leonesa, was decisive again just after the half-hour mark as he found the net from long range thanks to a kind deflection.