Arsenal head coach, Mikel Arteta, might be without at least six senior players, when they play Chelsea at Stamford Bridge on Tuesday.
Captain Pierre-Emerick Aubameyang is still suspended, after his red card against Crystal Palace.
Sokratis remains a doubt with illness and missed the 1-1 draw with Sheffield United on Saturday.
Sead Kolasinac and Reiss Nelson are expected to return after the winter break next month.
Calum Chambers and Kieran Tierney remain long term absentees.
A club statement on Monday, read: "Pierre-Emerick Aubameyang - Suspended. Further to receiving a red card at Crystal Palace on January 11, suspended for the game against Chelsea (a) and Bournemouth (a).
Calum Chambers - Left knee. Ruptured the anterior cruciate ligament of his left knee during Chelsea (h) on December 29. Successful surgery completed. Rehabilitation process expected to take between six and nine months.
"Sead Kolasinac - Left thigh strain. Hoping to return to full training in the winter break period after Burnley (a) on February 2.
"Reiss Nelson - Right hamstring. Hoping to return to full training in the winter break period after Burnley (a) on February 2.
"Sokratis - Illness. Being assessed ahead of Chelsea (a).
"Kieran Tierney - Right shoulder. Dislocated right shoulder during West Ham Utd (a) on December 9. Successful surgery completed. Rehabilitation process expected to take around three months, aiming to return to full training in March."