Lionel Messi netted a late winner, as Barcelona defeated 10-man Granada 1-0 at the Camp Nou on Sunday.
It was Quique Setien's first game in charge of the Spanish champions, after he took over from Ernesto Valverde last week.
However, the win did not come easy for Barca, as their visitors remained resolute in defence.
The game turned in the Catalan's favour after German Sanchez was sent off, before Messi won it with 14 minutes left.
Barcelona have now returned to the top of the LaLiga table, ahead of Real Madrid on goal difference.