Manchester United manager, Ole Gunnar Solskjaer, sent Jesse Lingard and Anthony Martial home from training on Friday, just 15 minutes after they arrived, because of illness.
ESPN reports that both players arrived at Carrington, but were asked to leave, after being checked over by club medical staff.
It is a further blow for Solskjaer ahead of United's FA Cup third round tie at Wolves on Saturday.
He is already without midfielders Paul Pogba and Scott McTominay.
"There are a couple of niggles, well not niggles, illnesses and colds, which is normal for this time," Solskjaer told a news conference on Friday.
"I'll have to see who wakes up tomorrow [Saturday] and feels OK. Today [Friday] we have got a training session as well."