Manchester United and Arsenal could be pegged against Cluj and Sporting Lisbon respectively in the Europa League round of 32.
United and the Gunners finished as respective group winners and are expected to face tricky contests in the knockout phase of the competition.
And according to SunSport's simulation, Arsenal could be given a tough fixture with Portuguese giants Sporting Lisbon as the Red Devils were drawn against Romanian side Cluj.
Lisbon finished second behind surprise package LASK while Cluj were runners up behind Celtic in Group E.
United last encounter with Cluj in a European competition was in 2012-13 season, winning away 2-1, but losing 1-0 at Old Trafford.
Scottish champions Celtic could face high flying Premier League side Wolves in an all-British affair in the round of 32.
Another interesting tie sees Rangers coming up against Basel while Frankfurt will square up against Champions League drop-out Inter Milan.
Roma were paired with Malmo as Bayer Leverkusen will set up an epic clash against Porto. Club Brugge will contest with Benfica and Ludogorets come face to face with Salzburg.
Other fixtures simulated by Sunsport includes: Gent vs Olympiakos, AZ Alkmaar vs Espnayol, APOEL vs Ajax, Kobenhavn vs Sevilla and Shakhtar vs Braga.